Inadine Non-Adherent Dressing

Inadine is a sterile, low-adherent antimicrobial wound dressing impregnated with povidone-iodine, designed for the management of ulcerative wounds and for antiseptic protection of minor burns, abrasions and minor traumatic skin-loss injuries.

The dressing consists of a knitted viscose fabric impregnated with an ointment containing 10% povidone-iodine (PVP-I) in a polyethylene glycol base, equivalent to approximately 1% available iodine. The iodine is gradually released from the dressing, providing a broad-spectrum antiseptic effect while the low-adherent construction helps minimise trauma to the wound bed during dressing changes.

Key features:

• Povidone-iodine antimicrobial wound dressing
• Contains 10% povidone-iodine
• Equivalent to approximately 1% available iodine
• Low-adherent knitted viscose construction
• Polyethylene glycol (PEG) ointment base
• Broad-spectrum antiseptic activity
• Demonstrated in-vitro activity against a range of microorganisms
• Povidone-iodine has demonstrated activity against MRSA
• Helps minimise adherence to the wound bed
• Helps protect granulation tissue during dressing removal
• Distinctive orange/brown colour
• Colour fades towards white as iodine is depleted
• Colour change helps indicate when the dressing may need replacing
• Requires an appropriate secondary dressing
• Sterile
• Single use
• Medical device

How Inadine works

Povidone-iodine acts as a reservoir from which iodine is gradually released into the wound environment.

The released iodine provides a broad-spectrum antimicrobial effect.

As iodine is released:

1. The dressing provides an antiseptic effect at the wound surface.
2. The concentration of iodine within the dressing gradually falls.
3. The dressing changes from its original orange/brown colour towards white.
4. This visible colour change provides a useful indication that the antiseptic activity has been depleted and the dressing should be reassessed or changed.

Suitable wound types

Inadine is indicated for the management of:

• Ulcerative wounds
• Minor burns
• Abrasions
• Minor traumatic skin-loss injuries

Clinical experience also supports its use in appropriately assessed chronic wounds including:

• Leg ulcers of different aetiologies
• Diabetic foot ulcers
• Pressure ulcers / pressure injuries

where an iodine-containing antiseptic dressing is clinically appropriate.

Inadine is particularly suited to superficial wounds with relatively low levels of exudate because the dressing itself has limited absorbency. A suitable secondary dressing is required to manage additional wound fluid.

How to use

Inadine should be used according to the manufacturer's instructions and the patient's wound-management plan.

1. Cleanse the wound according to appropriate clinical practice.
2. Dry the surrounding skin.
3. Open the sterile pouch.
4. Remove the protective backing from the dressing.
5. Apply Inadine directly to the wound surface.
6. Ensure appropriate contact between the dressing and wound bed.
7. Cover with a suitable secondary absorbent dressing.
8. Secure according to wound location and clinical requirements.

The secondary dressing should be selected according to the amount of wound exudate.

When to change Inadine

The dressing should be monitored regularly.

The original orange/brown colour gradually fades as iodine is released.

When the dressing becomes substantially white, its antiseptic effect has been depleted and it should normally be changed.

The actual change frequency varies considerably according to:

• Wound exudate
• Bacterial burden
• Wound size
• Clinical condition

In a more exuding wound, iodine may be depleted relatively quickly and the dressing may require frequent replacement.

Infection

Inadine provides an antiseptic effect, but it does not replace appropriate management of significant wound infection.

Seek clinical assessment if there is:

• Spreading redness
• Increasing swelling
• Increasing pain
• Purulent discharge
• Fever
• Cellulitis
• Rapid wound deterioration
• Signs of systemic infection

Systemic antibiotics or other treatment may be required where clinically indicated.

Important contraindications

Because Inadine contains povidone-iodine, systemic absorption of iodine can occur, particularly when it is used over larger wounds or for prolonged periods.

Current UK guidance based on the product precautions states that Inadine should not be used:

• In patients with known iodine hypersensitivity
• In patients with thyroid disease
• In patients being treated for significant kidney problems / renal impairment
• During pregnancy
• During breastfeeding
• In patients with Dühring's dermatitis herpetiformis
• Before or after radioactive iodine treatment, until permanent healing has occurred.

Medical supervision required

Inadine should be used under medical supervision:

• In newborn babies and infants up to 6 months
• On deep ulcerative wounds
• On extensive burns
• On large wounds or injuries
• Where treatment is required for more than one week.

Patients with thyroid or renal problems should not self-treat with an iodine dressing without professional advice.

Secondary dressing

Inadine is primarily a wound-contact layer, rather than an absorbent dressing.

It therefore normally requires an appropriate secondary dressing to:

• Absorb wound exudate
• Hold Inadine in position
• Protect the wound
• Provide additional fixation

The secondary dressing should be selected according to the wound and level of exudate.

Important information

Do not:

• Reuse
• Re-sterilise
• Use if the sterile pouch is damaged or already open
• Continue prolonged iodine treatment without clinical reassessment

The continued need for an antimicrobial dressing should be regularly reviewed.

Product type: Povidone-Iodine Antimicrobial Wound Contact Dressing
Dressing material: Low-adherent knitted viscose fabric
Active antimicrobial: Povidone-iodine (PVP-I)
Povidone-iodine concentration: 10%
Available iodine: Approximately 1%
Ointment base: Polyethylene glycol, purified water and PVP-I
Antimicrobial: Yes
Adhesive: No
Absorbency: Low
Secondary dressing required: Yes
Colour-change indicator: Yes – orange/brown towards white as iodine is depleted
Sterile: Yes
Single use: Yes
Classification: Medical device

Current UK presentations

Inadine – 5cm × 5cm

• Pack size: 25 dressings
• Product code: P01481
• PIP / Drug Tariff code: 037-1195
• NHS Supply Chain code: EKB501
• Current Solventum product ID: 7100343826
• BNF / dm+d code: 20030100120

Inadine – 9.5cm × 9.5cm

Pack of 10

• Product code: P01491
• Pack size: 10 dressings
• PIP / Drug Tariff code: 037-1229
• NHS Supply Chain code: EKB095
• Current Solventum product ID: 7100343827
• BNF / dm+d code: 20030100121

Pack of 25

• Product code: P01512
• Pack size: 25 dressings
• NHS Supply Chain code: EKB502
• Current Solventum product ID: 7100343828
• Solventum's UK catalogue does not list a Drug Tariff/PIP code for this 25-pack presentation.

Brand: Inadine™
Current brand owner: Solventum

Inadine should be selected according to wound type, exudate level and the clinical requirement for povidone-iodine antiseptic treatment. Because iodine can be systemically absorbed, prolonged use, large wounds and patients with thyroid or renal disease require particular caution and professional assessment.